P024171
Inderal 1 mg Injection
propranolol hydrochloride
Read all of this leaflet carefully before you start having this medicine.
- Keep this leaflet. You may need to read it again.
- If you have any further questions, ask your doctor or nurse.
- If any of the side effects get serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or nurse.
In this leaflet:
- 1. What Inderal Injection is and what it is used for
- 2. Before you have Inderal Injection
- 3. How to have Inderal Injection
- 4. Possible side effects
- 5. How to store Inderal Injection
- 6. Further information
What Inderal Injection is and what it is used for
Inderal Injection contains a medicine called propranolol. This belongs to a group of medicines called beta-blockers.
Inderal Injection is used in emergency situations to treat:
- Uneven heart beats (arrhythmias).
- Some thyroid problems (such as thyrotoxic crisis caused by an overactive thyroid gland).
It works by the effects it has on the heart and circulation and also on other parts of the body.
Before you have Inderal Injection
Do not have Inderal Injection if:
You have ever had asthma or wheezing. If this applies to you talk to your doctor or nurse.
- You are allergic (hypersensitive) to propranolol hydrochloride or any of the other ingredients in Inderal Injection (see Section 6: Further information).
- You have ever had any of the following heart problems:
- heart failure which is not under control (this usually makes you breathless and causes your ankles to swell)
- second- or third-degree heart block (a condition which may be treated by a pacemaker)
- very slow or very uneven heart beats, very low blood pressure or very poor circulation
- a type of chest pain (angina) called Prinzmetal’s angina.
- You have a tumour called phaeochromocytoma that is not being treated. This is usually near your kidney and can cause high blood pressure.
- You have been told that you have higher than normal levels of acid in your blood (metabolic acidosis).
- You have been fasting recently.
Do not have Inderal Injection if any of the above apply to you. If you are not sure, talk to your doctor or nurse before having Inderal Injection.
Take special care with Inderal Injection
Check with your doctor or nurse before having Inderal Injection if:
- You have ever had an allergic reaction, for example to insect stings.
- You have poor blood circulation or controlled heart failure.
- You have first-degree heart block.
- You have sharp chest pain which is not caused by exercise (unstable angina).
- You have problems with your kidneys. You may need to have some check-ups during your treatment.
- You have problems with your liver (such as cirrhosis of the liver). You may need to have some check-ups during your treatment.
- You have diabetes. Your medicine may change how you respond to having low blood sugar (hypoglycaemia). You may feel your heart beating faster.
- You have thyrotoxicosis (a condition caused by an overactive thyroid gland). Your medicine may hide the symptoms of thyrotoxicosis.
If you are not sure if any of the above apply to you, talk to your doctor or nurse before having Inderal Injection.
Taking other medicines
Please tell your doctor or nurse if you are taking, or have recently taken, any other medicines. This includes medicines that you buy without a prescription and herbal medicines. This is because Inderal Injection can affect the way some other medicines work and some medicines can have an effect on Inderal Injection.
In particular, tell your doctor if you are taking any of the following medicines:
- Clonidine (for high blood pressure or migraine). If you are taking clonidine and Inderal Injection together, do not stop taking clonidine unless your doctor tells you to do so. If you have to stop taking clonidine, your doctor will give you careful instructions about how to do it.
- Verapamil, diltiazem, nifedipine, nisoldipine, nicardipine, isradipine or lacidipine (for high blood pressure or chest pain).
- Hydralazine (for high blood pressure).
- Disopyramide, lidocaine, quinidine, amiodarone or propafenone (for an uneven heart beat).
- Digoxin (for heart problems)
- Warfarin (to thin the blood).
- Adrenaline, also known as epinephrine (a medicine that stimulates the heart).
- Ibuprofen or indometacin (for pain and inflammation).
- Ergotamine or dihydroergotamine (for migraine).
- Chlorpromazine or thioridazine (for mental illness).
- Cimetidine (for stomach problems).
- Rifampicin (for tuberculosis).
- Theophylline (for asthma).
- Insulin.
Operations
If you go into hospital to have an operation, tell the anaesthetist or medical staff that you are having Inderal Injection. This is because you can get low blood pressure (hypotension) if you are given certain anaesthetics while you are having Inderal Injection.
Having Inderal Injection with food and drink
If you frequently drink a lot of alcohol, talk to your doctor before having this medicine. This is because alcohol can affect how the medicine works.
Pregnancy and breast-feeding
Talk to your doctor before having this medicine if you are pregnant, might become pregnant or are breast-feeding.
Driving and using machines
- Your medicine is not likely to affect you being able to drive or use any tools or machines. However, it is best to wait to see how your medicine affects you before trying these activities.
- If you feel dizzy or tired when having this medicine, do not drive or use any tools or machines.
How to have Inderal Injection
Inderal Injection will be given to you by a doctor or a nurse. It is normally given in emergency situations. Your doctor will decide how much Inderal to give you. This depends on your age and your condition.
Adults
- The usual dose for an adult is 1 mg injected into a vein.
- This can be repeated if necessary up to a maximum dose of 10 mg.
Elderly people
If you are an elderly person your doctor may start you on a lower dose.
Children
The dose depends on the child’s age or weight.
Inderal Injection Side Effects
Like all medicines, Inderal Injection can cause side effects, although not everybody gets them.
The following side effects may happen with this medicine:
Common (affects less than 1 in 10 people)
- You may notice that your pulse rate becomes slower while you are having the injection. This is normal, but if you are concerned please tell your doctor about it.
- Cold hands and feet.
- Numbness and spasm in your fingers which is followed by warmth and pain (Raynaud’s disease).
- Disturbed sleep or nightmares.
- Feeling tired.
Uncommon (affects less than 1 in 100 people)
- Diarrhoea.
- Feeling sick (nausea).
- Being sick (vomiting).
Rare (affects less than 1 in 1,000 people)
- Heart block (which may cause an abnormal heart beat, dizziness, tiredness or fainting).
- Dizziness, particularly on standing up.
- Thinning of your hair.
- Mood changes.
- Feeling confused.
- Memory loss.
- Changes in personality (psychoses).
- Hallucinations.
- Tingling of your hands.
- Disturbances of vision.
- Dry eyes.
- Skin rash.
- Reduced numbers of platelets in your blood which may make you bruise more easily.
- Purplish marks on your skin.
Very rare (affects less than 1 in 10,000 people)
- Severe muscle weakness (myasthenia gravis).
- Changes to some of the cells or other parts of your blood. Your doctor may take blood samples every so often to check whether Inderal Injection has had any effect on your blood.
- Low levels of sugar in the blood (hypoglycaemia). This can happen in people with or without diabetes. This includes newborn babies, toddlers, children, elderly people, people on artificial kidneys (haemodialysis) or people taking medicines for diabetes. It may also happen in people who are fasting, have recently fasted or in people with a long-term liver disease.
Conditions that may get worse
If you have any of the following conditions, they may get worse when you start to have your medicine. This happens rarely affecting less than 1 in 1,000 people.
- Psoriasis (a skin condition).
- Being short of breath or having swollen ankles (if you have heart failure).
- Asthma or breathing problems.
- Poor circulation.
Do not be concerned by this list of side effects. You may not get any of them, especially because you are given the injection for only a short time. If any of the side effects get serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or nurse.
How to store Inderal Injection
- The doctor and hospital pharmacist are responsible for storing, using and disposing of Inderal Injection correctly.
- Your medicine should be kept below 30°C and away from strong light.
- Do not use your medicine after the expiry date which is stated on the carton. The expiry date refers to the last day of that month.
Further information
What Inderal Injection contains
The active substance is propranolol hydrochloride. Inderal Injection contains 1 mg of propranolol hydrochloride in 1 ml of injection.
The other ingredients are citric acid and water.
What Inderal Injection looks like and contents of the pack
It comes in a pack containing 10 ampoules. Each ampoule contains 1 ml of solution.
Marketing Authorisation Holder and Manufacturer
The Marketing Authorisation for Inderal Injection is held by
Inderal Injection is manufactured by
To listen to or request a copy of this leaflet in Braille, large print or audio please call, free of charge:
0800 198 5000 (UK only)
Please be ready to give the following information:
Product name: Inderal Injection
Reference numbers: 17901/0018
This is a service provided by the Royal National Institute of Blind People.
Leaflet prepared: May 2009.
© AstraZeneca 2009.
Inderal is a trade mark of the AstraZeneca group of companies.
CV 09 0063
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